Mutant Parkin Impairs Mitochondrial Function and Morphology in Human Fibroblasts
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چکیده
منابع مشابه
Mutant Parkin Impairs Mitochondrial Function and Morphology in Human Fibroblasts
BACKGROUND Mutations in Parkin are the most common cause of autosomal recessive Parkinson disease (PD). The mitochondrially localized E3 ubiquitin-protein ligase Parkin has been reported to be involved in respiratory chain function and mitochondrial dynamics. More recent publications also described a link between Parkin and mitophagy. METHODOLOGY/PRINCIPAL FINDINGS In this study, we investiga...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2010
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0012962